Fiber-optic endomicroscopy system for high-resolution nonlinear imaging of biological tissue
| Autor: | Yicong Wu, Xingde Li, Jiefeng Xi, Michael J. Cobb |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Optical fiber
Microscope Materials science genetic structures Swine Biomedical Engineering Physics::Optics High resolution In Vitro Techniques law.invention Optics Imaging Three-Dimensional law Endomicroscopy Animals Fiber Optical Fibers Endoscopes Microscopy business.industry Second-harmonic generation Signal Processing Computer-Assisted Biological tissue eye diseases Rats Nonlinear system Nonlinear Dynamics Optoelectronics sense organs business |
| Zdroj: | Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2008 |
| ISSN: | 2375-7477 |
| Popis: | A flexible fiber-optic endomicroscopy system was developed for nonlinear optical imaging of biological samples. Double-clad fiber and photonic bandgap fiber were employed in the endomicroscope for femtosecond pulse delivery, dispersion compensation, nonlinear optical signals collection and fast beam scanning. Three-dimensional imaging of biological tissues based on second harmonic generation and two-photon excited fluorescence was performed with the endomicroscope. The depth-resolved imaging results strongly suggest the potential of this flexible fiber-optic microscope system for real-time assessment of both epithelial and stromal structures in luminal organs. |
| Databáze: | OpenAIRE |
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