Printed electroceutical dressings for the inhibition of biofilms and treatment of chronic wounds
| Autor: | Rachel Heald, Vish V. Subramaniam, Molly Marie Bennett, Sarah A. Salyer, Devendra H. Dusane, Shaurya Prakash, Varun Lochab, Prashanth Mohana Sundaram, Joseph West, Paul Stoodley |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Polymicrobial infection integumentary system business.industry Mechanical Engineering 030106 microbiology Biofilm Article Microbiology 03 medical and health sciences 030104 developmental biology In vivo Wound dressing Initial treatment Medicine Clinical case Electrical and Electronic Engineering Bacterial inhibition business Intervention treatment |
| Zdroj: | J Microelectromech Syst |
| ISSN: | 2020-0129 |
| Popis: | We report on an innovative, fabric-based conformable, and easily fabricated electroceutical wound dressing that inhibits bacterial biofilm infections and shows significant promise for healing chronic wounds. Cyclic voltammetry demonstrates the ability of the electroceutical to produce reactive oxygen species, primarily HOCl that is responsible for bacterial inhibition. In vitro investigation with the lawn biofilm grown on a soft tissue mimic assay shows the efficacy of the dressing against both Gram-positive and Gram-negative bacteria in the biofilm form. In vivo, the printed electroceutical dressing was utilized as an intervention treatment for a canine subject with a non-healing wound due to a year-long persistent polymicrobial infection. The clinical case study with the canine subject exhibited the applicability in a clinical setting with the results showing infection inhibition within 11 days of initial treatment. This printed electroceutical dressing was integrated with a Bluetooth® enabled circuit allowing remote monitoring of the current flow within the wound bed. The potential to monitor wounds remotely in real-time with a Bluetooth® enabled circuit proposes a new physical biomarker for management of infected, chronic wounds. [2020-0129] |
| Databáze: | OpenAIRE |
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