Orally active cephalosporins and penicillins
| Autor: | D. L. Wenstrup, P. F. Hoffman, E. H. W. Böhme, R J Baumann, M. J. Vaal, R. A. Schnettler, B. L. Harrison, F. J. Mccarty, R. E. Bambury, R. C. Erickson |
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| Rok vydání: | 1980 |
| Předmět: |
Male
medicine.drug_class Injections Subcutaneous Cephalosporin Administration Oral Microbial Sensitivity Tests Penicillins Pharmacology Methylenedioxy chemistry.chemical_compound Mice Structure-Activity Relationship In vivo Drug Discovery polycyclic compounds medicine Structure–activity relationship Animals Chemistry Biological activity Bacterial Infections In vitro Cephalosporins Orally active Molecular Medicine STREPTOCOCCAL INFECTIONS |
| Zdroj: | Journal of medicinal chemistry. 23(4) |
| ISSN: | 0022-2623 |
| Popis: | A number of orally active cephalosporins and penicillins with interesting biological activity were synthesized. Two of these, 7-[[[3,4-(methylenedioxy)phenyl]glycyl]amino]deacetoxycephalosporanic acid and 7-[[2-(2,3-dihydro-5-benzofuranyl)glycyl]amino]deacetoxycephalosporanic acid were considerably more active than cephalexin both in vitro and in vivo against staphylococcal and streptococcal infections. |
| Databáze: | OpenAIRE |
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