Murine liver response to Allium sativum treatment during infection induced-trypanosomiasis
| Autor: | Esam M. Al-Shaebi, Ahmed S. Alazzouni, Mohamed A. Dkhil, Saleh Al-Quraishy, Mona Khalil |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
0301 basic medicine animal structures Antioxidant QH301-705.5 medicine.medical_treatment Parasitemia Pharmacology 01 natural sciences Mice 03 medical and health sciences chemistry.chemical_compound Sativum Trypanosomiasis medicine Biology (General) biology Glutathione Trypanosoma evansi Malondialdehyde biology.organism_classification medicine.disease 030104 developmental biology Liver chemistry Catalase biology.protein Allium sativum General Agricultural and Biological Sciences 010606 plant biology & botany |
| Zdroj: | Saudi Journal of Biological Sciences, Vol 28, Iss 6, Pp 3270-3274 (2021) |
| ISSN: | 1319-562X |
| Popis: | Hepatic injury induced by trypanosomiasis is one of the major health problems not only to human but also to wild and domestic animals. This study aimed to evaluate the hepatoprotective role of Allium sativum extract (ASE) against Trypanosoma evansi infection in mice. Animals were divided into 4 groups. Group I received only saline while group II received ASE (20 mg/Kg). Animals of group III and group IV were infected with T. evansi. The latter group was treated with ASE. The infrared spectroscopic analysis of A. sativum extract exhibited bands between 3700 cm−1 and 599 cm−1. On day 4 post T. evansi infection, ASE decreased the parasitemia by about 15 fold. Also, ASE regulated the number of erythrocytes and leucocytes and the hemoglobin content. In addition, the histopathological damage was reduced after treatment with ASE. Moreover, the oxidant and the antioxidant markers (glutathione, malondialdehyde and catalase) were regulated in the infected-treated animals. Collectively, the results proved the protective role of ASE against T. evansi infection in mice. |
| Databáze: | OpenAIRE |
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