A single, comprehensive non-invasive cardiovascular assessment in pulmonary arterial hypertension: Combined computed tomography pulmonary and coronary angiography
| Autor: | James Stirrup, Henryk Kafka, Edward D. Nicol, Michael B. Rubens, Simon P.G. Padley, Philip J. Kilner, Michael A. Gatzoulis |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Heart malformation Hypertension Pulmonary Coronary Angiography Ventricular Function Left Coronary artery disease Electrocardiography Young Adult Internal medicine medicine Pulmonary angiography Humans Prospective Studies Observer Variation Lung Ejection fraction business.industry Reproducibility of Results Stroke Volume Stroke volume Middle Aged medicine.disease Magnetic Resonance Imaging Pulmonary hypertension medicine.anatomical_structure Ventricular Function Right Cardiology Female Tomography X-Ray Computed Cardiology and Cardiovascular Medicine business Artery |
| Zdroj: | International Journal of Cardiology. 136:278-288 |
| ISSN: | 0167-5273 |
| Popis: | Comprehensive assessment of pulmonary arterial hypertension (PAH) should identify structural causes and subsequent cardiopulmonary consequences of PAH. This currently requires the use of several imaging modalities. Computed tomography (CT) is routinely used for pulmonary angiography (CTPA). Our aim was to assess whether combined pulmonary and coronary angiography (CTPCA) using ECG-gated, multi-detector CT (MDCT) would allow satisfactory pulmonary angiography, coronary angiography and ventriculography to be combined into a single acquisition using a single imaging modality.We assessed CTPCA in 30 consecutive adult patients (mean age 41+/-11 years) with a diagnosis of PAH. In addition to the standard assessment of lung parenchyma and pulmonary vasculature, we assessed the ability of CT to satisfactorily visualise coronary vessels and biventricular function. Functional analysis included: end-diastolic volume (EDV), end-systolic volume (EDV), stroke volume (SV) and ejection fraction (EF) and mass and these parameters were correlated with same day cardiovascular magnetic resonance (CMR).Lung parenchyma, pulmonary and coronary vessels were fully visualised in all cases. Ventriculography correlated well with same day CMR (RVEDV r=0.94, +19.5+/-49.2 ml, RVESV r=0.93, +11.1+/-46.4 ml, RVSV r=0.60, +8.5+/-41.6 ml, RVEF r=0.77, -0.5+/-21.3% and RV mass r=0.73, -17.3+/-60.4 g, LVEDV r=0.68, +12.2+/-110 ml, LVESV r=0.69, +7.5+/-59.7 ml, LVSV r=0.54, +2.5+/-40.6 ml, LVEF r=0.73, -1.9+/-20.8% and LV mass r=0.87, -20.5+/-22.5 g (all p0.001)). Associated congenital cardiovascular malformations were characterised in 22/30 cases.A CTPCA protocol allows safe, fast, comprehensive, non-invasive assessment of the possible anatomical causes and cardiopulmonary sequelae of PAH in adult patients, demonstrating congenital heart abnormalities, coronary artery disease and cardiac function. |
| Databáze: | OpenAIRE |
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