The relationship between domain-specific subjective cognitive decline and Alzheimer's pathology in normal elderly adults

Autor: Hakmook Kang, Suzanne L. Baker, Harry E. Gwirtsman, Paul A. Newhouse, Sepideh Shokouhi, Alzheimer’s Disease Neuroimaging Initiative, Kimberly Albert, Alexander C. Conley
Rok vydání: 2019
Předmět:
0301 basic medicine
Fluorine Radioisotopes
Aging
Disease
Neurodegenerative
Audiology
Alzheimer's Disease
Correlation
Cognition
0302 clinical medicine
80 and over
2.1 Biological and endogenous factors
Medicine
Neurofibrillary tau tangles
Aetiology
Cognitive decline
Aged
80 and over
Aniline Compounds
medicine.diagnostic_test
General Neuroscience
Brain
Regression
Mental Health
Positron emission tomography
Neurological
Ethylene Glycols
medicine.medical_specialty
Amyloid beta plaques
Clinical Sciences
Neuroimaging
tau Proteins
Article
03 medical and health sciences
Clinical Research
Alzheimer Disease
Acquired Cognitive Impairment
[(18)F]flortaucipir
Humans
Cognitive Dysfunction
Pathological
Aged
Neurology & Neurosurgery
Amyloid beta-Peptides
business.industry
Alzheimer's Disease Neuroimaging Initiative
Neurosciences
Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)
Brain Disorders
030104 developmental biology
Positron-Emission Tomography
Subjective cognitive decline
Dementia
[(18)F]florbetapir
Neurology (clinical)
Radiopharmaceuticals
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
Developmental Biology
Zdroj: Neurobiol Aging
ISSN: 0197-4580
DOI: 10.1016/j.neurobiolaging.2019.05.011
Popis: We evaluated the associations of subjective (self-reported everyday cognition [ECog]) and objective cognitive measures with regional amyloid-β (Aβ) and tau accumulation in 86 clinically normal elderly subjects from the Alzheimer's Disease Neuroimaging Initiative. Regression analyses were conducted to identify whether individual ECog domains (Memory, Language, Organization, Planning, Visuospatial, and Divided Attention) were equally or differentially associated with regional [18F]florbetapir and [18F]flortaucipir uptake and how these associations compared to those obtained with objective cognitive measures. A texture analysis, the weighted 2-point correlation, was used as an additional approach for estimating the whole-brain tau burden without positron emission tomography intensity normalization. Although the strongest models for ECog domains included either tau (planning and visuospatial) or Aβ (memory and organization), the strongest models for all objective measures included Aβ. In Aβ-negative participants, the strongest models for all ECog domains of executive functioning included tau. Our results indicate differential associations of individual subjective cognitive domains with Aβ and tau in clinically normal adults. Detailed characterization of ECog may render a valuable prescreening tool for pathological prediction.
Databáze: OpenAIRE
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