Pretransplantation Donor-Recipient Pair Seroreactivity Against BK Polyomavirus Predicts Viremia and Nephropathy After Kidney Transplantation

Autor: Eric C. J. Claas, Françoise Arnold, Frans H.J. Claas, C.S. van der Blij-de Brouwer, J.W. de Fijter, Antoine Touzé, Joris I. Rotmans, E.W. van Zwet, Marko J.K. Mallat, Herman F. Wunderink, Aloys C.M. Kroes, Geert W. Haasnoot, E. van der Meijden, Mariet C.W. Feltkamp
Přispěvatelé: Department of Medical Microbiology, Leiden University Medical Center (LUMC), Department of Nephrology, Department of Immunohematology and Blood Transfusion, Department of Medical Statistics and Bioinformatics, UR Infectiologie animale et Santé publique ( UR IASP ), Institut National de la Recherche Agronomique ( INRA ), Dutch Kidney Foundation grant 13A1D302, UR Infectiologie animale et Santé publique (UR IASP), Institut National de la Recherche Agronomique (INRA), Infectiologie et Santé Publique (UMR ISP), Institut National de la Recherche Agronomique (INRA)-Université de Tours, Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
basic (laboratory) research/science
renal pelvis
renal failure
[SDV]Life Sciences [q-bio]
BK polyomavirus
basic (laboratory) research
serology
kidney transplantation/nephrology
risk stratification
030230 surgery
Kidney Function Tests
Serology
0302 clinical medicine
réplication virale
Living Donors
Immunology and Allergy
risk factors
Pharmacology (medical)
Kidney transplantation
science
virus replication
Netherlands
Kidney
Hazard ratio
transplantation d'organe
rein
risk assessment
Middle Aged
Prognosis
practice
polyoma
3. Good health
seroreactivity
risk assessment/risk stratification
immunoglobulin g
medicine.anatomical_structure
nephropathy
Female
Kidney Diseases
viral: BK/JC/polyoma
Glomerular Filtration Rate
infection and infectious agents
kidney disease: infectious
infectious disease
nephrology
JC
polyomavirus
kidney transplantation
test sérologique
Viremia
clinical research/practice
Nephropathy
immunoglobuline g
03 medical and health sciences
medicine
Humans
donors and donation: donor-derived infections
Retrospective Studies
Polyomavirus Infections
Transplantation
viremia
viral: BK
[ SDV ] Life Sciences [q-bio]
business.industry
Retrospective cohort study
medicine.disease
Virology
Transplant Recipients
Tumor Virus Infections
030104 developmental biology
clinical research
BK Virus
Immunology
néphropathie
business
Follow-Up Studies
Zdroj: American Journal of Transplantation
American Journal of Transplantation, Wiley, 2017, 17 (1), pp.161-172. 〈10.1111/ajt.13880〉
American Journal of Transplantation, 17(1), 161-172
American Journal of Transplantation, Wiley, 2017, 17 (1), pp.161-172. ⟨10.1111/ajt.13880⟩
ISSN: 1600-6135
1600-6143
DOI: 10.1111/ajt.13880〉
Popis: International audience; Kidney transplant donors are not currently implicated in predicting BK polyomavirus (BKPyV) infection in kidney transplant recipients. It has been postulated, however, that BKPyV infection originates from the kidney allograft. Because BKPyV seroreactivity correlates with BKPyV replication and thus might mirror the infectious load, we investigated whether BKPyV seroreactivity of the donor predicts viremia and BKPyV-associated nephropathy (BKPyVAN) in the recipient. In a retrospective cohort of 407 living kidney donor-recipient pairs, pretransplantation donor and recipient sera were tested for BKPyV IgG levels and correlated with the occurrence of recipient BKPyV viremia and BKPyVAN within 1 year after transplantation. Donor BKPyV IgG level was strongly associated with BKPyV viremia and BKPyVAN (p < 0.001), whereas recipient BKPyV seroreactivity showed a nonsignificant inverse trend. Pairing of high-BKPyV-seroreactive donors with low-seroreactive recipients resulted in a 10-fold increased risk of BKPyV viremia (hazard ratio 10.1, 95% CI 3.5-29.0, p < 0.001). In multivariate analysis, donor BKPyV seroreactivity was the strongest pretransplantation factor associated with viremia (p < 0.001) and BKPyVAN (p = 0.007). The proportional relationship between donor BKPyV seroreactivity and recipient infection suggests that donor BKPyV seroreactivity reflects the infectious load of the kidney allograft and calls for the use of pretransplantation BKPyV serological testing of (potential) donors and recipients.
Databáze: OpenAIRE
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