Engineered liposomes and virosomes for delivery of macromolecules
| Autor: | S. Grimaldi, A. Giuliani, L. Ferroni, A. Lisi, N. Santoro, D. Pozzi |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Herpesvirus 4
Human Proteolipids Immunology Fluorescent Antibody Technique Biology Membrane Fusion Immune system Drug Delivery Systems Phagocytosis Viral Envelope Proteins proteoliposome Virology Anion Exchange Protein 1 Erythrocyte Tumor Cells Cultured Macrophage Humans band 3 protein phagocytic activity drug vector ebv virosome Cellular compartment Liposome Macrophages Virosome Cell culture Drug delivery Liposomes Drug carrier |
| Zdroj: | Research in virology 146 (1995): 289–293. info:cnr-pdr/source/autori:Grimaldi S, Giuliani A, Giuliani A, Ferroni L, Lisi A, Santoro N, Pozzi D./titolo:Engineered liposomes and virosomes for delivery of macromolecules./doi:/rivista:Research in virology/anno:1995/pagina_da:289/pagina_a:293/intervallo_pagine:289–293/volume:146 |
| ISSN: | 0923-2516 |
| Popis: | In order to utilize virosomes or proteoliposomes for the delivery of drugs or macromolecules to specific pathologic target cells we elaborated a system to shuttle drugs to solid tissue (liver) as well as to the macrophages, a crucial cellular compartment of the immune system. Using virosomes prepared from the P3HR1 strain of Epstein-Barr virus, we demonstrated that these particles fused with human hepatocarcinoma cell line Li7A and therefore might be used as drug vectors. Furthermore, we report that proteoliposomes prepared by reconstituting in a cocktail of phosphatidylserine-phosphatidylcholine the anion transporter band 3 protein markedly increased the phagocytic activity of macrophages in culture. This could represent a new device to be used as a drug delivery system to enhance specific macrophagic functions. |
| Databáze: | OpenAIRE |
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