Hyperglycemia predicts mortality after CABG: postoperative hyperglycemia predicts dramatic increases in mortality after coronary artery bypass graft surgery
| Autor: | Roger C. Millar, John H. Mitchell, Donald L. Lappé, Kent W. Jones, A. Steven Cain, Samuel L. Abbate, Diane Marshall, Shane R. Stevenson, Holly L. Rimmasch, Thomas K. French, Colleen Roberts |
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| Rok vydání: | 2007 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Endocrinology Diabetes and Metabolism Logistic regression Diabetes Complications Endocrinology Risk Factors Diabetes mellitus Internal Medicine medicine Odds Ratio Humans Postoperative Period Coronary Artery Bypass Stroke Glycemic Aged Retrospective Studies business.industry Retrospective cohort study Odds ratio Fasting Length of Stay Middle Aged medicine.disease Respiration Artificial Surgery medicine.anatomical_structure Treatment Outcome Hyperglycemia Complication business Artery |
| Zdroj: | Journal of diabetes and its complications. 22(6) |
| ISSN: | 1873-460X |
| Popis: | Risk of morbidity and mortality after coronary artery bypass graft surgery (CABG) is higher in patients with clinical diabetes mellitus (DM). We evaluated whether outcomes are affected by postoperative hyperglycemia in CABG patients independent of preoperative DM diagnosis.A total of 2297 consecutive CABG patients were studied. The first glucose value after surgery completion (mean 15 min) was tested as a predictor of outcome. Primary outcome variables were prolonged ventilation (24 h), deep sternal wound infection, renal failure, permanent stroke, any reoperation, length of stay (14 days) and mortality. All outcomes except for prolonged ventilation and length of stay were tracked out to 30 days postoperatively. Patients were stratified by glycemic control: Low (glucose80), normal (referent, glucose 80-110), high (glucose 111-200) and very high (glucose200 mg/dl). Multivariable logistic regression was used to determine the independent predictive value of glycemic groups, adjusted for outcome specific risk scores from the Society of Thoracic Surgeons model.Patient distribution among groups low through very high were 44 (1.9%), 476 (20.7%), 1425 (62.0%) and 352 (15.3%). Greater complication rates were noted in the very high group when compared with the referent group: prolonged ventilation (adjusted odds ratio (OR)=2.66, P.001), length of stay14 days (adjusted OR=2.06, P=.004) and mortality (adjusted OR=7.71, P.001).Patients with blood glucose values200 mg/dl immediately after CABG had an increased risk of complications, including mortality, independent of a clinical diagnosis of DM. This study documents the high risk associated with early postoperative hyperglycemia in this group, suggesting the need for prospective trials of glycemic control. |
| Databáze: | OpenAIRE |
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