The effect of depressive symptoms on cognition in patients with fibromyalgia

Autor: Olalla Varela, Lluís Rosselló, Maite Garolera, Olga Gelonch, Joan Valls, Josep Pifarré, Gerard Castellà
Rok vydání: 2018
Předmět:
Male
Fibromyalgia
Physiology
Social Sciences
lcsh:Medicine
Cognition
0302 clinical medicine
Medicine and Health Sciences
Psychology
Medicine
Attention
Depressió psíquica
lcsh:Science
Depression (differential diagnoses)
Cognitive Impairment
Multidisciplinary
Depression
Cognitive Neurology
Cognitive flexibility
Neuromuscular Diseases
Middle Aged
Executive functions
Neurology
Cognició
Anxiety
Female
medicine.symptom
Research Article
Clinical psychology
Adult
Cognitive Neuroscience
03 medical and health sciences
Rheumatology
Mental Health and Psychiatry
Humans
Effects of sleep deprivation on cognitive performance
030203 arthritis & rheumatology
Fibromiàlgia
Mood Disorders
business.industry
Working memory
lcsh:R
Cognitive Psychology
Biology and Life Sciences
medicine.disease
Cognitive Science
lcsh:Q
Physiological Processes
Sleep
Sleep Disorders
business
030217 neurology & neurosurgery
Neuroscience
Zdroj: PLoS ONE, Vol 13, Iss 7, p e0200057 (2018)
Recercat. Dipósit de la Recerca de Catalunya
instname
Repositorio Abierto de la UdL
Universitad de Lleida
PLoS ONE
ISSN: 1932-6203
Popis: Background Fibromyalgia (FM) patients frequently complain of cognitive problems, but it remains unclear whether these cognitive complaints can be attributed to a dysfunction of the central nervous system or if they can be explained by other factors associated with the disease, such as depression, anxiety and sleep dysfunction. Methods One hundred and ten patients with FM were compared with thirty-three patients diagnosed with a depressive disorder (DD) and fifty healthy controls (HC). Several measures of attention and executive functions were used to make these comparisons and the patients were also asked to complete questionnaires on depression, anxiety and sleep quality. Univariate analyses of covariance (ANCOVA) were performed to identify and control confounders and multiple linear models were used to examine the effects of fibromyalgia and depression on cognitive measures. Results FM and HC differed significantly with respect to depression, anxiety and sleep dysfunction, whereas FM and DD did not differ in terms of symptoms of depression and anxiety. However, FM was associated with a worse quality of sleep than DD. Comparisons of cognitive performance between groups showed that short-term and working memory and inattention measures were only associated with symptoms of depression, whereas selective attention was associated with both depression and fibromyalgia, and processing speed, cognitive flexibility and inhibitory control showed a significant interaction between depression and fibromyalgia. Moreover, cognitive flexibility and inhibition abilities were specifically associated with FM. Conclusion FM patients show a cluster of cognitive impairment in the attentional and executive domains, although some of the symptoms observed could be explained by the severity of the symptoms of depression, while others seem to depend on the effects of fibromyalgia. Implications of the findings for the understanding and management of cognitive impairment of FM patients are discussed. Funding: This work was supported in part by Biomedical Research Institute of Lleida (IRB-Lleida) funds.The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Databáze: OpenAIRE
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