Current opinion on an emergence of drug resistant strains of Plasmodium falciparum through genetic alterations
| Autor: | Pavithra Venkateshaiah, Donepudi Siva Mallika, Seelam Jeevan Amos, Krs Sambasiva Rao, K Kasturi |
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| Rok vydání: | 2012 |
| Předmět: |
Drug
biology business.industry media_common.quotation_subject Plasmodium falciparum General Medicine Drug resistance Disease Stage specific protein targets Pharmacology Hypothesis biology.organism_classification medicine.disease Virology Malaria medicine Stage specific Antimalarial drugs business Gene Pathogen Mutations media_common |
| Zdroj: | Bioinformation |
| ISSN: | 0973-2063 |
| Popis: | The human malarial parasite Plasmodium falciparum is one of the world's most devastating pathogen. Its capability to regulate its genes under various stages of its life cycle as well as under unfavourable environmental conditions has led to the development of vaccine resistant strains. Similarly, under drug pressure it develops mutations in the target genes. These mutations confer mid and high-level resistance to the antimalarial drugs. Increasing a resistance of malaria parasites to conventional antimalarial drugs is an important factor contributing to the persistence of the disease as a major health threat. This article reviews current knowledge of stage specific malarial targets, antimalarial drugs and the mutations that have led to the emergence of resistant strains. |
| Databáze: | OpenAIRE |
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