Cell Intrinsic and Systemic Metabolism in Tumor Immunity and Immunotherapy
| Autor: | Michael F. Coleman, Stephen D. Hursting, Alyssa J. Cozzo, Suhas K. Etigunta, Alexander J. Pfeil |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research obesity medicine.medical_treatment T cell Calorie restriction Cell Review lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Immune system medicine cancer Tumor microenvironment business.industry Cancer Immunotherapy calorie restriction medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cancer cell Cancer research immune checkpoint inhibition business metabolism |
| Zdroj: | Cancers, Vol 12, Iss 852, p 852 (2020) Cancers |
| ISSN: | 2072-6694 |
| Popis: | Immune checkpoint inhibitor (ICI) therapy has shown extraordinary promise at treating cancers otherwise resistant to treatment. However, for ICI therapy to be effective, it must overcome the metabolic limitations of the tumor microenvironment. Tumor metabolism has long been understood to be highly dysregulated, with potent immunosuppressive effects. Moreover, T cell activation and longevity within the tumor microenvironment are intimately tied to T cell metabolism and are required for the long-term efficacy of ICI therapy. We discuss in this review the intersection of metabolic competition in the tumor microenvironment, T cell activation and metabolism, the roles of tumor cell metabolism in immune evasion, and the impact of host metabolism in determining immune surveillance and ICI therapy outcomes. We also discussed the effects of obesity and calorie restriction—two important systemic metabolic perturbations that impact intrinsic metabolic pathways in T cells as well as cancer cells. |
| Databáze: | OpenAIRE |
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