Preliminary description of focal segmental glomerulosclerosis in patients with renovascular disease
Autor: | Manuel Pascual, V Nickeleit, Nina Tolkoff-Rubin, Robert B. Colvin, Ravi Thadhani |
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Rok vydání: | 1996 |
Předmět: |
Male
medicine.medical_specialty Pathology Biopsy Kidney Glomerulus Urology Renal function urologic and male genital diseases Focal segmental glomerulosclerosis medicine Renal mass Humans In patient Aged Proteinuria Glomerulosclerosis Focal Segmental urogenital system Glomerular proteinuria business.industry General Medicine Middle Aged medicine.disease female genital diseases and pregnancy complications Radiography Hypertension Renovascular Etiology Female Renovascular disease medicine.symptom business Follow-Up Studies |
Zdroj: | The Lancet. 347:231-233 |
ISSN: | 0140-6736 |
Popis: | Summary Background Primary and secondary forms of focal segmental glomerulosclerosis (FSGS) are common causes of glomerular proteinuria. Secondary forms of FSGS seem to be the result of adaptive changes that follow a reduction in renal mass. We saw an elderly patient with severe bilateral renal vascular disease (RVD) who had FSGS on percutaneous biopsy. To find out whether elderly patients with atherosclerotic RVD are predisposed to the development of FSGS, we reviewed all cases of FSGS at our institution between 1990 and 1995. Methods We identified 59 cases of biopsy-proven FSGS and examined clinical, histological, and radiographic records. Findings Of the 59 patients, 24 were older than 50 years; eight of these had RVD. No patient under the age of 50 had RVD. Seven of the eight patients with RVD and FSGS had substantial proteinuria at presentation. All had typical glomerular lesions with focal segmental tuft collapse and synechiae; other glomeruli were hypertrophic. All patients showed further decline in renal function on follow-up. Interpretation The association of FSGS and RVD may represent an under-recognised aetiology of significant proteinuria in elderly patients. |
Databáze: | OpenAIRE |
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