Mechanisms involved in the development of diabetic retinopathy induced by oxidative stress
| Autor: | Diego Zamora de la Cruz, Ernestina Hernández García, David Calderón Guzmán, Hugo Juárez Olguín, Armando Valenzuela Peraza, Monica Punzo Soto |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Physiology Clinical Biochemistry Disease Review Article medicine.disease_cause Bioinformatics Biochemistry Retina 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus medicine Animals Humans In patient chemistry.chemical_classification Reactive oxygen species Diabetic Retinopathy business.industry Biochemistry (medical) Cell Biology Diabetic retinopathy medicine.disease Antioxidant capacity Oxidative Stress 030104 developmental biology Endocrinology chemistry Poor control 030221 ophthalmology & optometry business Reactive Oxygen Species Oxidative stress Biomarkers |
| Zdroj: | Redox report : communications in free radical research. 22(1) |
| ISSN: | 1743-2928 |
| Popis: | Background: Diabetic retinopathy (DR) is one of the main complications in patients with diabetes and has been the leading cause of visual loss since 1990. Oxidative stress is a biological process resulting from excessive production of reactive oxygen species (ROS). This process contributes to the development of many diseases and disease complications. ROS interact with various cellular components to induce cell injury. Fortunately, there is an antioxidan t system that protects organisms against ROS. Indeed, when ROS exceed antioxidant capacity, the resulting cell injury can cause diverse physiological and pathological changes that could lead to a disease like DR. Objective: This paper reviews the possible mechanisms of common and novel biomarkers involved in the development of DR and explores how these biomarkers could be used to monitor the damage induced by oxidative stress in DR, which is a significant complication in people with diabetes. Conclusion: The poor control of glucemy in pacients with DB has been shown contribute to the development of complications in eyes as DR. |
| Databáze: | OpenAIRE |
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