The conserved theme of ribosome hibernation: from bacteria to chloroplasts of plants
| Autor: | Felix Willmund, Raphael Trösch |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Chloroplasts Stringent response 030106 microbiology Clinical Biochemistry Cell Down-Regulation Firmicutes Bacterial Physiological Phenomena Biochemistry Ribosome 03 medical and health sciences Eukaryotic translation Bacterial Proteins Gene expression Protein biosynthesis medicine Molecular Biology Plant Physiological Phenomena Plant Proteins Chemistry Translation (biology) Genetic code Cell biology 030104 developmental biology medicine.anatomical_structure Protein Biosynthesis Ribosomes |
| Zdroj: | Biological Chemistry. 400:879-893 |
| ISSN: | 1437-4315 1431-6730 |
| Popis: | Cells are highly adaptive systems that respond and adapt to changing environmental conditions such as temperature fluctuations or altered nutrient availability. Such acclimation processes involve reprogramming of the cellular gene expression profile, tuning of protein synthesis, remodeling of metabolic pathways and morphological changes of the cell shape. Nutrient starvation can lead to limited energy supply and consequently, remodeling of protein synthesis is one of the key steps of regulation since the translation of the genetic code into functional polypeptides may consume up to 40% of a cell’s energy during proliferation. In eukaryotic cells, downregulation of protein synthesis during stress is mainly mediated by modification of the translation initiation factors. Prokaryotic cells suppress protein synthesis by the active formation of dimeric so-called ‘hibernating’ 100S ribosome complexes. Such a transition involves a number of proteins which are found in various forms in prokaryotes but also in chloroplasts of plants. Here, we review the current understanding of these hibernation factors and elaborate conserved principles which are shared between species. |
| Databáze: | OpenAIRE |
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