Subclassification of patients with solitary hepatocellular carcinoma based on post-hepatectomy survival: a large retrospective study
| Autor: | Bang-De Xiang, Wen-Feng Gong, Yan-Yan Wang, Ling-Hui Pan, Le-Qun Li, Lei Liu, Jian-Hong Zhong, Qi-Shun Zhang, Qin Zhenming, Lu-Nan Qi, Hong-Gui Qin |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Solitary fibrous tumor Carcinoma Hepatocellular Hepatic resection medicine.medical_treatment Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Overall survival Hepatectomy Humans Neoplasm Invasiveness Postoperative Period Survival analysis Aged Tumor size business.industry Liver Neoplasms Retrospective cohort study General Medicine Middle Aged medicine.disease Prognosis Survival Analysis Tumor Burden Treatment Outcome Liver 030220 oncology & carcinogenesis Hepatocellular carcinoma Solitary Fibrous Tumors 030211 gastroenterology & hepatology Female Neoplasm Recurrence Local business |
| Zdroj: | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 37(4) |
| ISSN: | 1423-0380 |
| Popis: | Official guidelines group together all cases of solitary hepatocellular carcinoma (HCC) without macroscopic vascular invasion, regardless of tumor size. Here, we examined whether this is justified based on overall survival (OS) after hepatic resection (HR). Patients with newly diagnosed solitary HCC treated by initial HR from January 2004 to October 2013 were classified into six groups based on tumor size (in 2-cm increments). Combining adjacent categories with similar OS led to three groups: ≤5 cm (n = 426),5 and ≤8 cm (n = 229), and8 cm (n = 202). Among all patients, median survival time was 62 months, and OS was 95 % at 1 year, 73 % at 3 years, and 54 % at 5 years. Patients in the ≤5 cm group showed significantly higher OS (P 0.001) and lower tumor recurrence (P = 0.004) than those in the5 and ≤8 cm group, who in turn showed significantly higher OS (P = 0.003) and lower tumor recurrence (P = 0.021) than those in the8 cm group. Our results suggest that patients with solitary HCC should be subclassified based on tumor size for more accurate prognosis. We propose defining solitary HCC tumors5 and ≤8 cm as "large" and tumors8 cm as "huge". |
| Databáze: | OpenAIRE |
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