Circulating leptin, soluble leptin receptor, free leptin index, visfatin and selected leptin and leptin receptor gene polymorphisms in sporadic breast cancer
| Autor: | Eric H. Karunanayake, Ananda Wijayasiri, Indrani Amarasinghe, Chrishani Rodrigo, Kamani H. Tennekoon, Kanishka De Silva |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Leptin 0301 basic medicine medicine.medical_specialty Genotype Endocrinology Diabetes and Metabolism Adipokine Breast Neoplasms Polymorphism Single Nucleotide Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Breast cancer Blood serum Gene Frequency Internal medicine Humans Medicine Genetic Predisposition to Disease Nicotinamide Phosphoribosyltransferase Aged Leptin receptor business.industry digestive oral and skin physiology Case-control study Middle Aged medicine.disease 030104 developmental biology Risk factors for breast cancer Case-Control Studies 030220 oncology & carcinogenesis Cytokines Receptors Leptin Female Menopause business Body mass index hormones hormone substitutes and hormone antagonists |
| Zdroj: | Endocrine Journal. 64:393-401 |
| ISSN: | 1348-4540 0918-8959 |
| Popis: | Leptin and visfatin are implicated in breast cancer risk but studies accounting for bioavailability of leptin are sparse. Reports on the association of leptin gene (LEP) and leptin receptor gene (LEPR) polymorphisms with breast cancer are also inconsistent. Only a very few studies have examined biochemical and genetic variables concomitantly in the same cohort. A matched pairs study was carried out to ascertain whether plasma leptin, soluble leptin receptor, free leptin index (leptin/soluble leptin receptor), serum visfatin and selected LEP and LEPR polymorphisms are risk factors for sporadic breast cancer. Newly diagnosed sporadic breast cancer patients (N=80) were matched for age, body mass index (BMI) and menopausal status with healthy controls. Plasma leptin, soluble leptin receptor and serum visfatin were measured by enzyme-immunoassay. LEP -2548 A/G and LEPR K109R, LEPR Q223R polymorphisms were determined by genotyping. Leptin (p=0.0234), leptin/BMI (p=0.0468), free leptin index (p |
| Databáze: | OpenAIRE |
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