Omega-3 Index and Clinical Outcomes of Severe COVID-19: Preliminary Results of a Cross-Sectional Study
Autor: | Jose M. Müller, Madelaine Pradenas, Gustavo Lago, Franco Ravera, Muriel Ramírez-Santana, Eduardo Cañón, Daniella Castañeda, Rodrigo Zapata B, Juan Vásquez |
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Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Coronavirus disease 2019 (COVID-19) Docosahexaenoic Acids Cross-sectional study Health Toxicology and Mutagenesis medicine.medical_treatment 030209 endocrinology & metabolism Omega 3 index 03 medical and health sciences 0302 clinical medicine Internal medicine Healthy control Fatty Acids Omega-3 Omega-3 fatty acids Medicine Animals Humans Omega-3 Index Pandemics Mechanical ventilation business.industry SARS-CoV-2 Communication Public Health Environmental and Occupational Health COVID-19 Eicosapentaenoic acid 030104 developmental biology Cross-Sectional Studies Quartile Eicosapentaenoic Acid Docosahexaenoic acid inflammation business |
Zdroj: | International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health, Vol 18, Iss 7722, p 7722 (2021) |
ISSN: | 1660-4601 |
Popis: | The potentially detrimental effects of the worldwide deficiency of Omega-3 fatty acids on the COVID-19 pandemic have been underestimated. The Omega-3 Index (O3I), clinical variables, biometric indices, and nutritional information were directly determined for 74 patients with severe COVID-19 and 10 healthy quality-control subjects. The relationships between the OI3 and mechanical ventilation (MV) and death were analyzed. Results: Patients with COVID-19 exhibited low O3I (mean: 4.15%; range: 3.06–6.14%)—consistent with insufficient fish and Omega-3 supplement consumption, and markedly lower than the healthy control subjects (mean: 7.84%; range: 4.65–10.71%). Inverse associations were observed between O3I and MV (OR = 0.459; C.I.: 0.211–0.997) and death (OR = 0.28; C.I.: 0.08–0.985) in severe COVID-19, even after adjusting for sex, age, and well-known risk factors. Conclusion: We present preliminary evidence to support the hypothesis that the risk of severe COVID-19 can be stratified by the O3I quartile. Further investigations are needed to assess the value of the O3I as a blood marker for COVID-19. |
Databáze: | OpenAIRE |
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