DEFECTIVE IODINATION OF TYROSINE A CAUSE OF NODULAR GOITER?*
| Autor: | Vernon N. Dodson, Carr, William H. Beierwaltes, A. Edward, John C. Floyd |
|---|---|
| Rok vydání: | 1960 |
| Předmět: |
endocrine system
medicine.medical_specialty Pathology Goiter Halogenation endocrine system diseases Endocrinology Diabetes and Metabolism Clinical Biochemistry Biochemistry chemistry.chemical_compound Endocrinology Internal medicine medicine Humans Hashimoto Disease Euthyroid Tyrosine business.industry Thyroid disease digestive oral and skin physiology Biochemistry (medical) Thyroid medicine.disease eye diseases Thiouracil medicine.anatomical_structure chemistry Radioactive iodine business Goiter Nodular |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 20:881-888 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-20-6-881 |
| Popis: | Twenty patients with colloid nodular goiter, 7 patients with Hashimoto's struma, and 15 patients without thyroid disease (all non-deaf) were tested with radioactive iodine and potassium thiocyanate for a thyroidal defect in iodination of tyrosine. In the cases of colloid nodular goiter with a family history of goiter there was a higher incidence and more severe degree of defective iodination of tyrosine than in the cases of colloid nodular goiter without a family history of goiter. Defective iodination of tyrosine was demonstrated in 1 sibling with proved colloid nodular goiter and in 1 with Hashimoto's struma. Iodination of tyrosine was impaired in 1 patient with her fourth recurrence of colloid nodular goiter. These data suggest that defective iodination of tyrosine is not uncommon in euthyroid non-deaf subjects with colloid nodular goiter, and may occur on a familial basis. ATRACER dose of radioactive iodine (I131) is normally incorporated into the tyrosine molecule shortly after entering the ... |
| Databáze: | OpenAIRE |
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