Predicting Response to Neoadjuvant Therapy in Colorectal Cancer Patients the Role of Messenger-and Micro-RNA Profiling
| Autor: | Chiara Ceccaroli, Emilio Di Maria, Alberto Izzotti, Filippo Grillo Ruggieri, Sara Schenone, Marta Geretto |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Mirna signature
Oncology Cancer Research medicine.medical_specialty Colorectal cancer medicine.medical_treatment Review lcsh:RC254-282 Internal medicine microRNA medicine neoadjuvant therapy Neoadjuvant therapy RNA biomarkers colorectal neoplasms messenger miRNAs business.industry Clinical study design medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens business |
| Zdroj: | Cancers Cancers, Vol 12, Iss 1652, p 1652 (2020) |
| ISSN: | 2072-6694 |
| Popis: | Colorectal cancer patients’ responses to neoadjuvant therapy undergo broad inter-individual variations. The aim of this systematic review is to identify a molecular signature that is predictive of colon cancer downstaging and/or downgrading after neoadjuvant therapy. Among the hundreds analysed in the available studies, only 19 messenger-RNAs (mRNAs) and six micro-RNAs (miRNAs) were differentially expressed in responders versus non-responders in two or more independent studies. Therefore, a mRNA/miRNA signature can be designed accordingly, with limitations caused by the retrospective nature of these studies, the heterogeneity in study designs and the downgrading/downstaging assessment criteria. This signature can be proposed to tailor neoadjuvant therapy regimens on an individual basis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|