Identification of transcriptional targets of GSK3 involved in glioblastoma invasion
| Autor: | Anke Brüning-Richardson, Filomena Esteves, Josie Hayes, Julia V. Cockle, Sean E. Lawler, Michel Mittelbronn, Alastair Droop, Susan C Short, Azzam Ismail, Marjorie Boissinot, Vinton Cheng, Georgia Mavria, Ruth Morton, Daniel Tams |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cancer Research Cancer Biology medicine.disease Abstracts 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Oncology Downregulation and upregulation GSK-3 RNA interference 030220 oncology & carcinogenesis Glioma Cancer cell medicine Cancer research Neurology (clinical) Candidate Disease Gene GSK3B |
| Zdroj: | Neuro-Oncology. 20:i26-i26 |
| ISSN: | 1523-5866 1522-8517 |
| Popis: | INTRODUCTION Glioblastoma multiforme remains one of the most difficult to treat cancers due to the highly infiltrative nature of cancer cells. Targeting the invasive properties of glioblastoma presents a novel treatment avenue. Recently, specific GSK-3 beta (GSK3b) inhibitors such as Bio-Indirubin (BIO), have been described that inhibit the migratory activity of glioma cells. In this study, the GSK-3b downstream targets were investigated. |
| Databáze: | OpenAIRE |
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