Calcium oscillations triggered by cardiotonic steroids

Autor:	Khodus Gr, Jacopo M. Fontana, Ievgeniia Burlaka, Anita Aperia, Hjalmar Brismar
Rok vydání:	2013
Předmět:	Protein subunit chemistry.chemical_element Apoptosis Calcium Biochemistry Ouabain Cardiac Glycosides chemistry.chemical_compound medicine Animals Humans Calcium Signaling Na+/K+-ATPase Molecular Biology NF-kappa B NF-κB Cell Biology respiratory system Inositol trisphosphate receptor Cell biology chemistry Ion pump Sodium-Potassium-Exchanging ATPase Signal Transduction medicine.drug Proto-oncogene tyrosine-protein kinase Src
Zdroj:	FEBS Journal. 280:5450-5455
ISSN:	1742-464X
DOI:	10.1111/febs.12448
Popis:	Na(+), K(+)-ATPase (NKA) is well known for its function as an ion pump. Studies during the last decade have revealed an additional role for NKA as a signal transducer. In this brief review, we describe how cardiotonic steroids, which are highly specific NKA ligands, trigger slow Ca(2+) oscillations by promoting the interaction between NKA and the inositol trisphosphate receptor, and how this Ca(2+) signal activates the NF-κB subunit p65 and increases the expression of the antiapoptotic factor Bcl-xL. The potential tissue-protective effects of this signal are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e3aca905fc5a237a62549b31d3a23f https://doi.org/10.1111/febs.12448 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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