Stage-by-Stage Effects of Surgical Margin Status on Biochemical Failure after Radical Prostatectomy in Patients with Clinically Localized Prostate Cancer
| Autor: | Ali Memis, Omer Gokhan Doluoglu, Alp Özgür Akdemir, Mesut Çetinkaya, Binhan Kagan Aktas, Cetin Volkan Oztekin, Cüneyt Özden |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Oncology medicine.medical_specialty Surgical margin Biopsy Urology medicine.medical_treatment Prostate cancer Risk Factors Internal medicine medicine Humans Neoplasm Metastasis Stage (cooking) Aged Retrospective Studies Prostatectomy Univariate analysis medicine.diagnostic_test business.industry fungi Prostate Prostatic Neoplasms Middle Aged Prostate-Specific Antigen Prognosis medicine.disease Prostate-specific antigen Lymphatic Metastasis Disease Progression Regression Analysis Positive Surgical Margin business |
| Zdroj: | Urologia Internationalis. 86:156-160 |
| ISSN: | 1423-0399 0042-1138 |
| DOI: | 10.1159/000322840 |
| Popis: | Purpose: To evaluate the effects of pathological stage and surgical margin status on biochemical failure rates after radical prostatectomy (RP). Materials and Methods: The records of 205 patients who underwent RP for clinically localized prostate cancer (CaP) were evaluated. Known risk factors for biochemical failure (BF) were analyzed using univariate and multivariate logistic regression analysis. The effects of surgical margin status together with pathological stage on BF were evaluated. p values lower than 0.05 were accepted to be statistically significant. Results: Pathological stage, positive surgical margin (PSM), seminal vesicle invasion, lymph node involvement, biopsy Gleason score and postoperative Gleason score were the factors associated with BF in univariate analysis. Logistic regression analysis revealed that pT3a patients with PSM had a significant BF rate when compared to pT2 patients with a negative surgical margin (NSM) (OR 7.46, p = 0.002). pT3a patients with a NSM had a similar BF rate to that of pT2 patients with PSM. Conclusions: pT2 patients with PSM had a similar biochemical prognosis to that of pT3a patients without PSM, implicating that a PSM may have a negative effect on prognosis similar to that of extracapsular invasion. |
| Databáze: | OpenAIRE |
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