Anti-contactin-associated protein-like 2 antibody-associated cerebellar ataxia: A case report and literature review
| Autor: | Junwei Hao, Huiqing Dong, Zhandong Qiu, Jingsi Wang, Zheng Liu, Dawei Li |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Pathology medicine.medical_specialty Cerebellum Cerebellar Ataxia medicine.medical_treatment Immunology Nerve Tissue Proteins Disease Autoantigens Autoimmune Diseases 03 medical and health sciences 0302 clinical medicine medicine Immunology and Allergy Humans Immunologic Factors Autoantibodies Autoimmune encephalitis Cerebellar ataxia biology business.industry Limbic encephalitis Membrane Proteins Immunotherapy Middle Aged medicine.disease 030104 developmental biology medicine.anatomical_structure nervous system Neurology biology.protein Cerebellar atrophy Neurology (clinical) medicine.symptom Antibody Atrophy business 030217 neurology & neurosurgery |
| Zdroj: | Journal of neuroimmunology. 353 |
| ISSN: | 1872-8421 |
| Popis: | The spectrum of anti-contactin-associated protein-like 2 (CASPR2) antibody-associated disease is expanding and the involvement of cerebellum was reported in the past few years. We report a 45-year-old male with chronically progressive cerebellar ataxia. CASPR2 antibodies were detected in his serum and cerebellar atrophy was observed on MRI. His symptoms improved prominently with steroids and intravenous immunoglobulins. 23 cases with CASPR2 antibodies and cerebellar ataxia were identified from previous publications. Most of patients showed acute or subacute onset with other typical presentations of anti-CASPR2 antibody-associated disease, such as limbic encephalitis. Immunotherapy was effective in the majority of patients. |
| Databáze: | OpenAIRE |
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