Effects of sedation on clinical, gasometric, and respiratory muscle parameters in critically ill chronic obstructive pulmonary disease patients
| Autor: | Wafaa A.H Gadalla, Emad Zarief Kamel, Atef F Alkarn, Mohamed F Abdelghany, Mohammad G. A. Khalaf |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
lcsh:RC705-779
Mechanical ventilation COPD Respiratory rate business.industry medicine.medical_treatment lcsh:Medical emergencies. Critical care. Intensive care. First aid lcsh:Diseases of the respiratory system lcsh:RC86-88.9 mechanical ventilation medicine.disease chronic obstructive pulmonary disease Blood pressure sedation Anesthesia Intensive care Respiratory muscle Medicine Intubation Arterial blood business intensive care |
| Zdroj: | The Egyptian Journal of Bronchology, Vol 13, Iss 3, Pp 328-334 (2019) |
| ISSN: | 2314-8551 1687-8426 |
| Popis: | Background Severe chronic obstructive pulmonary disease (COPD) exacerbation requiring mechanical ventilation is commonly encountered in the ICU. Sedation is necessary to facilitate mechanical ventilation. The effect of no-sedation strategy on different patient parameters on the ventilator has not yet been well studied. The aim of this study was to test the efficacy of no-sedation protocol in controlling COPD patient’s gasometric and clinical parameters during mechanical ventilation. Patients and methods Patients with COPD who required mechanical ventilation were randomized to either: sedated with daily interruption (control group) (n=50) or nonsedated group (n=47). The change in the partial pressure of arterial CO2 (PaCO2) was the primary outcome measure. Secondary outcome measures included: changes in pH, heart rate (HR), mean arterial blood pressure (MAP), respiratory rate, airway occlusion pressure (P0.1), and negative inspiratory force (NIF). Recordings for arterial blood gases, HR, MAP, and respiratory rate were performed as baseline at intubation, 1, 2, 12, 24, and 48h after intubation. NIF and P0.1 were recorded 48 h after intubation. Results No significant difference was found in baseline recordings of PaCO2, pH, HR, MAP, and respiratory rate between the sedated and nonsedated groups. Further recordings of PaCO2 (P_1, P_2, P_3, and P_4 |
| Databáze: | OpenAIRE |
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