Analysis of factors influencing aspiration risk following chemoradiation for oropharyngeal cancer
| Autor: | Herbert J. Smith, C Lemanski, T. Martinez, Ulf Karlsson, Paul Vos, Sabah Sallah, Ly M. Nguyen, Nam P. Nguyen, C. C. Moltz, Suresh Dutta, C. Frank, P D Nguyen |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Tonsillar Carcinoma Antimetabolites Antineoplastic Radiation-Sensitizing Agents Aspiration risk Tonsillar Neoplasms Locally advanced Contrast Media Risk Factors Antineoplastic Combined Chemotherapy Protocols medicine Humans Radiology Nuclear Medicine and imaging Risk factor Aged Retrospective Studies business.industry Respiratory Aspiration Cancer General Medicine Middle Aged medicine.disease Dysphagia Combined Modality Therapy Texas Surgery Tongue Neoplasms Oropharyngeal Neoplasms Treatment Outcome Oropharyngeal Carcinoma Fluorouracil medicine.symptom Barium Sulfate Cisplatin business Deglutition Disorders Chemoradiotherapy |
| Zdroj: | The British journal of radiology. 82(980) |
| ISSN: | 1748-880X |
| Popis: | Our aim was to identify risk factors for aspiration following concurrent chemoradiation for oropharyngeal cancer. 46 patients with locally advanced oropharyngeal carcinoma underwent concurrent chemoradiation at our institution. All patients underwent modified barium swallow to assess dysphagia severity and to determine the need for continued tube feedings after treatment. Dysphagia severity was graded as 1-7. There were 5 Grade 2, 11 Grade 3, 5 Grade 4, 5 Grade 5, 10 Grade 6 and 10 Grade 7 scores. 25 patients (54%) developed aspiration (5 trace, 20 severe). The aspiration rate for T1-T2 and T3-T4 tumours was 31% and 67%, respectively (p = 0.03). There was no statistical difference in the aspiration rate between the base of the tongue and tonsillar carcinoma (p = 0.23). Despite anatomical organ preservation, most patients with locally advanced oropharyngeal carcinoma had moderate to severe dysphagia after chemoradiation. Patients with large tumours had a significant risk of developing aspiration following treatment. |
| Databáze: | OpenAIRE |
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