A Low Concentration of Ethanol Impairs Learning but Not Motor and Sensory Behavior in Drosophila Larvae

Autor: Farhan Husain, Daniel Goan, Kathryn Fife, Jacxelyn Moran, Jeffrey Sun, Amar Bhat, Foram Desai, Ruchita R. Shah, Michael M. Hatch, Allen C. Zhong, William Y. Chen, Alfredo Ghezzi, Nigel S. Atkinson, Amanda M. Cady, Jascha B. Pohl, Kristina Najjar, Kareem B. Haroun, Omar Hariri, Brooks G. Robinson, Wen-Ke Li, Ryan M. Godinez, Melvin Young, Tuan Tran, Jonathan Corpuz, Jeff Hooten, Sukant Khurana
Rok vydání: 2012
Předmět:
lcsh:Medicine
Social and Behavioral Sciences
Toxicology
chemistry.chemical_compound
Learning and Memory
0302 clinical medicine
Neurobiology of Disease and Regeneration
Psychology
lcsh:Science
0303 health sciences
Multidisciplinary
Drosophila Melanogaster
Temperature
Animal Models
Sensory Systems
Smell
Larva
Shock (circulatory)
Models
Animal
Medicine
Public Health
Olfactory Learning
Drosophila melanogaster
medicine.symptom
Alcohol
Research Article
medicine.medical_specialty
Chromatography
Gas
Neurophysiology
Sensory system
Motor Activity
Biology
03 medical and health sciences
Model Organisms
Internal medicine
Neuroplasticity
medicine
Animals
Learning
030304 developmental biology
Motor Systems
Ethanol
Dose-Response Relationship
Drug
lcsh:R
Cognitive Psychology
biology.organism_classification
Associative learning
Endocrinology
chemistry
lcsh:Q
030217 neurology & neurosurgery
Neuroscience
Drosophila larvae
Zdroj: PLoS ONE
PLoS ONE, Vol 7, Iss 5, p e37394 (2012)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0037394
Popis: Drosophila melanogaster has proven to be a useful model system for the genetic analysis of ethanol-associated behaviors. However, past studies have focused on the response of the adult fly to large, and often sedating, doses of ethanol. The pharmacological effects of low and moderate quantities of ethanol have remained understudied. In this study, we tested the acute effects of low doses of ethanol (∼7 mM internal concentration) on Drosophila larvae. While ethanol did not affect locomotion or the response to an odorant, we observed that ethanol impaired associative olfactory learning when the heat shock unconditioned stimulus (US) intensity was low but not when the heat shock US intensity was high. We determined that the reduction in learning at low US intensity was not a result of ethanol anesthesia since ethanol-treated larvae responded to the heat shock in the same manner as untreated animals. Instead, low doses of ethanol likely impair the neuronal plasticity that underlies olfactory associative learning. This impairment in learning was reversible indicating that exposure to low doses of ethanol does not leave any long lasting behavioral or physiological effects.
Databáze: OpenAIRE
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