Inhibition of fish brain ATPases by aldrin-transdiol, aldrin, dieldrin and photodieldrin
| Autor: | D. Desaiah, R.B. Koch |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Photochemistry
Metabolite ATPase Biophysics Naphthols Biology Biochemistry chemistry.chemical_compound Dieldrin Animals Neurotoxin Magnesium Aldrin Molecular Biology Adenosine Triphosphatases Sodium Fishes Brain Cell Biology biology.organism_classification Mitochondria Photodieldrin Enzyme Activation Kinetics chemistry Ictalurus Potassium biology.protein Oligomycins Catfish |
| Zdroj: | Biochemical and Biophysical Research Communications. 64:13-19 |
| ISSN: | 0006-291X |
| Popis: | The sensitivity of catfish, Ictalurus punctatus, brain ATPase activities to cyclodiene compounds was investigated. The ATPase system showed differences in sensitivity to aldrin, dieldrin and photodieldrin. However, aldrin-transdiol (a more terminal metabolite of dieldrin and reported as a more potent neurotoxin than dieldrin) had no effect on any ATPase activity from fish brain homogenates. Mitochondrial Mg2+ ATPase was the most sensitive ATPase to the cyclodiene compounds tested. The possibility that the neurotoxic effects of these compounds is a secondary response resulting from mitochondrial Mg2+ ATPase inhibition is discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|