Posttranslational Regulation of Mycobacterium tuberculosis Extracytoplasmic-Function Sigma Factor σ L and Roles in Virulence and in Global Regulation of Gene Expression

Autor:	Elisa Dainese, Sébastien Rodrigue, Roberta Provvedi, Liette Laflamme, Giorgio Palù, Luc Gaudreau, Issar Smith, Giovanni Fadda, Riccardo Manganelli, Giovanni Delogu, Ryszard Brzezinski
Rok vydání:	2006
Předmět:	Virulence Factors Molecular Sequence Data Immunology Virulence Sigma Factor Microbiology Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA Mycobacterium tuberculosis Mice Sigma factor Gene expression Animals Post-translational regulation Tuberculosis Pulmonary Gene Regulation of gene expression Genetics Mice Inbred BALB C Base Sequence biology Gene Expression Regulation Bacterial biology.organism_classification Molecular Pathogenesis Mice Inbred C57BL Infectious Diseases Mice Inbred DBA Parasitology Protein Processing Post-Translational Function (biology)
Zdroj:	Infection and Immunity. 74:2457-2461
ISSN:	1098-5522 0019-9567
Popis:	In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL - rslA mutant strain was significantly attenuated in a mouse model of infection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d8dec3f26ba84559b033b111e1f40e https://doi.org/10.1128/iai.74.4.2457-2461.2006 Zobrazit plný text záznamu