Cutting edge: Toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis
| Autor: | Alexandra Fehrenbach, Norbert Reiling, Carsten J. Kirschning, Svenja Kröger, Sanna Goyert, Christoph Hölscher, Stefan Ehlers |
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| Rok vydání: | 2002 |
| Předmět: |
Tuberculosis
CD14 Immunology Colony Count Microbial Dose-Response Relationship Immunologic Lipopolysaccharide Receptors Bone Marrow Cells Receptors Cell Surface Biology Proinflammatory cytokine Microbiology Mycobacterium tuberculosis Mice Administration Inhalation medicine Immunology and Allergy Animals Drosophila Proteins Lung Aerosols Mice Knockout Toll-like receptor Mice Inbred BALB C Mice Inbred C3H Membrane Glycoproteins Macrophages Toll-Like Receptors Pattern recognition receptor medicine.disease biology.organism_classification Immunity Innate Toll-Like Receptor 2 Mice Inbred C57BL Toll-Like Receptor 4 TLR2 TLR4 Cytokines |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0022-1767 |
| Popis: | Innate resistance against Mycobacterium tuberculosis is thought to depend critically on engagement of pattern recognition receptors on macrophages. However, the relative contribution of these receptors for containing M. tuberculosis infection has remained unexplored in vivo. To address this issue, we infected mice defective in CD14, TLR2, or TLR4 with M. tuberculosis by aerosol. Following infection with 100 mycobacteria, either mutant strain was as resistant as congenic control mice. Granuloma formation, macrophage activation, and secretion of proinflammatory cytokines in response to low-dose aerosol infection were identical in mutant and control mice. However, high-dose aerosol challenge with 2000 CFU M. tuberculosis revealed TLR2-, but not TLR4-defective mice to be more susceptible than control mice. In conclusion, while TLR2 signaling contributes to innate resistance against M. tuberculosis in borderline situations, its function, and that of CD14 and TLR4, in initiating protective responses against naturally low-dose airborne infection is redundant. |
| Databáze: | OpenAIRE |
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