Neuroendocrine-Immune Surveillance of Osteosarcoma: Emerging Hypothesis
| Autor: | Francesco Chiappelli, A. Ibarra, George W. Bernard, M. Fiala, Paolo Prolo, A. Dovio, A. Angeli, M.L. Sartori |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
musculoskeletal diseases Programmed cell death Adolescent Neuroimmunomodulation Apoptosis Bone Neoplasms Bone matrix Biology Lymphocyte Activation 03 medical and health sciences 0302 clinical medicine Immune system medicine Humans 030212 general & internal medicine Child General Dentistry Aged 030203 arthritis & rheumatology Osteosarcoma Cancer Middle Aged medicine.disease Immune surveillance Young population Immunology Cytokines |
| Zdroj: | Journal of Dental Research. 82:417-421 |
| ISSN: | 1544-0591 0022-0345 |
| DOI: | 10.1177/154405910308200603 |
| Popis: | Osteosarcoma is a bone-forming cancer predominantly found in children and adolescents more often than in adults. Osteosarcoma of the gnathic apparatus is relatively rare in the young population, and this condition becomes a concern of clinical dentists for predominantly the middle-aged and aging patient groups. Osteosarcomas are invaded by lymphocytes, which exhibit signs of activation. The immune processes that are engaged within the malignant bone matrix involve the production of cytokines, which regulate the process of apoptotic programed cell death. This paper discusses the mechanisms by which apoptosis of osteosarcoma cells is modulated by the neuroendocrine-immune system, and potential physiological implications. |
| Databáze: | OpenAIRE |
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