Association between IL-17A and IL-17F gene polymorphism and susceptibility in inflammatory arthritis: A meta-analysis
| Autor: | Ming Shao, Yuting Chen, Xing Gao, Zongwen Shuai, Wei Xu, Jixiang Deng, Shengqian Xu, Faming Pan, Hui Yang, Shi-Yang Guan, Shanshan Xu |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Inflammatory arthritis Immunology Arthritis Polymorphism Single Nucleotide Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Osteoarthritis medicine Genetic predisposition Odds Ratio Immunology and Allergy Humans Genetic Predisposition to Disease Spondylitis Ankylosing Allele Ankylosing spondylitis business.industry Interleukin-17 medicine.disease 030104 developmental biology Rheumatoid arthritis Interleukin 17 Gene polymorphism business 030215 immunology |
| Zdroj: | Clinical immunology (Orlando, Fla.). 213 |
| ISSN: | 1521-7035 |
| Popis: | The association between Interleukin (IL)-17A and IL-17F gene polymorphism with inflammatory arthritis were inconsistent among previous studies. This meta-analysis aimed to determine the association between IL-17A and IL-17F gene polymorphism with ankylosing spondylitis (AS), osteoarthritis (OA) and rheumatoid arthritis (RA).We searched Medline up to August 2019. The summary Odds Ratio (OR) with corresponding 95% confidence intervals (CIs) was calculated to evaluate the relationship between IL-17A and IL-17F gene polymorphism with genetic susceptibility of AS, OA and RA.A total of 19 studies with 5298 cases and 5675 healthy controls were included. There were significant associations between rs2275913 G allele with OA, RA susceptibility (P .05) but not AS. Subgroup analysis by ethnicity indicated that rs763780 C allele was closely related to AS and OA in Caucasian populations (P .001) but not Mongolians. A significant association between rs763780 and RA susceptibility was detected in Caucasian populations (P .05).IL-17F gene rs763780 C allele confers increased risk of inflammatory arthritis in Caucasians; IL-17A gene rs2275913 G allele are protective for OA susceptibility in Mongolians. More well-designed studies with larger sample size are needed to elucidate the role of IL-17A gene rs2275913 G allele in inflammatory arthritis, especially AS. |
| Databáze: | OpenAIRE |
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