Synthesis, Dimerization, and Biological Activity of Hexaoxygenated Chalcones Related to Calythropsin and Combretastatins
| Autor: | François Tillequin, Prokopios Magiatis, Elisabeth Seguin, Lin Rui Chao, Abdelhakim Elomri, Alexios-Leandros Skaltsounis |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Chalcone
Spectrophotometry Infrared Photochemistry Swine Stereochemistry Cyclobutane Inhibitory Concentration 50 Mice Structure-Activity Relationship chemistry.chemical_compound Tubulin Tumor Cells Cultured medicine Animals Structure–activity relationship Cytotoxicity Nuclear Magnetic Resonance Biomolecular Calythropsin Leukemia Molecular Structure Chemistry Brain Biological activity Mechanism of action Molecular Medicine Aldol condensation Drug Screening Assays Antitumor medicine.symptom |
| Zdroj: | Natural Product Letters. 16:187-193 |
| ISSN: | 1057-5634 |
| DOI: | 10.1080/10575630290010993 |
| Popis: | Five new hexaoxygenated chalcones and one new chalcone photodimer were synthesized and their cytotoxicity against leukemia cell line L-1210 was studied. The three more active compounds were tested for their activity on the inhibition and promotion of tubulin assembly and it was found that these chalcones do not interfere with the tubulin-microtubule system at cytotoxic concentrations, and therefore operate by some different mechanism of action. |
| Databáze: | OpenAIRE |
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