Pericarditis and myocarditis long after SARS-CoV-2 infection: a cross-sectional descriptive study in health-care workers

Autor: Rocio Eiros, Oihane Perez-Escurza, Pedro L. Sánchez, Clara Sanchez-Pablo, Laura Macias-Alvarez, Manuel Barreiro-Pérez, Elena Díaz-Peláez, Alba Torres-Valle, Soraya Merchán, Inés Toranzo, David González-Calle, Quentin Lecrevisse, Alba Pérez-Pons, Guillermo Oliva-Ariza, Alberto Orfao, Eduardo Villacorta, Julia Almeida, Rafael Fluxa, Ana Martín-García, José L. Bravo-Grandez, Blanca Fuentes-Herrero
Přispěvatelé: Centro de Investigación Biomédica en Red Enfermedades Cardiovaculares (España), Centro de Investigación Biomédica en Red Cáncer (España), Instituto de Salud Carlos III, European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Eiros, Rocío [0000-0002-9488-2555], Barreiro-Pérez, Manuel [0000-0001-7489-2935], Pérez-Pons, Alba [0000-0002-5805-1391], Torres-Valle, Alba [0000-0002-9485-5696], Sanchez-Pablo, Clara [0000-0002-7656-7156], Gonzalez-Calle, David [0000-0001-9051-0124], Perez-Escurza, Oihane [0000-0002-6966-4337], Fuentes-Herrero, Blanca [0000-0002-4038-8439], Orfao, Alberto [0000-0002-0007-7230], Sánchez, Pedro L. [0000-0002-1402-0526], Eiros, Rocío, Barreiro-Pérez, Manuel, Pérez-Pons, Alba, Torres-Valle, Alba, Sanchez-Pablo, Clara, Gonzalez-Calle, David, Perez-Escurza, Oihane, Fuentes-Herrero, Blanca, Orfao, Alberto, Sánchez, Pedro L.
Rok vydání: 2020
Předmět:
Zdroj: Digital.CSIC. Repositorio Institucional del CSIC
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Popis: Background: Cardiac sequelae of past SARS-CoV-2 infection are still poorly documented. We conducted a cross-sectional study in health-care workers to report evidence of pericarditis and myocarditis after SARS-CoV-2 infection.
Methods We studied 139 health-care workers with confirmed past SARS-CoV-2 infection (103 diagnosed by RT-PCR and 36 by serology). Participants underwent clinical assessment, electrocardiography, laboratory tests including immune cell profiling and cardiac magnetic resonance (CMR) imaging. Pericarditis was diagnosed when classical criteria were present, and the diagnosis of myocarditis was based on the updated CMR Lake-Louise-Criteria.
Results: Median age was 52 years (IQR 41-57), 100 (72%) were women, and 23 (16%) were previously hospitalized for Covid-19 pneumonia. At examination (10.4 [9.3-11.0] weeks after infection-like symptoms), all participants presented hemodynamic stability. Chest pain, dyspnoea or palpitations were observed in 58 (42%) participants; electrocardiographic abnormalities in 69 (50%); NT-pro-BNP was elevated in 11 (8%); troponin in 1 (1%); and CMR abnormalities in 104 (75%). Isolated pericarditis was diagnosed in 4 (3%) participants, myopericarditis in 15 (11%) and isolated myocarditis in 36 (26%). Participants diagnosed by RT-PCR were more likely to still present symptoms than participants diagnosed by serology (73 [71%] vs 18 [50%]; p=0.027); nonetheless, the prevalence of pericarditis or myocarditis was high in both groups (44 [43%] vs 11 [31%]; p=0.238). Most participants (101 [73%]) showed altered immune cell counts in blood, particularly decreased eosinophil (37 [27%]; p
Conclusions: Pericarditis and myocarditis with clinical stability are frequent long after SARS-CoV-2 infection, even in presently asymptomatic subjects. These observations will probably apply to the general population infected and may indicate that cardiac sequelae might occur late in association with an altered (delayed) innate and adaptative immune response.
This study was supported by CIBERCV (CB16/11/00374), CIBERONC (CB16/12/00400) and the COV20/00386 grant from the Instituto de Salud Carlos III and FEDER, Ministerio de Ciencia e Innovacion, Madrid, Spain.
Databáze: OpenAIRE
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