Neuroendocrine Differentiation of Prostate Cancer Metastases Evidenced 'in Vivo' by 68Ga-DOTANOC PET/CT: Two Cases
| Autor: | Giordano Savelli, Renato Pagani, Giuseppe Valmadre, Giorgio Biasiotto, Elisa Pecini, Matteo Falcone, Roberto Barbieri, Claudio Ghimenton, Alfredo Muni, Chiara Minari |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Oncology
PCA3 Cancer Research medicine.medical_specialty Positron emission tomography Somatostatin receptor business.industry Cancer Case Report medicine.disease Neuroendocrine differentiation Prostate cancer medicine.anatomical_structure Prostate Internal medicine medicine Adjuvant therapy Hormonal therapy business Somatostatin receptors Castration-resistant prostate cancer |
| Zdroj: | World Journal of Oncology |
| ISSN: | 1920-454X 1920-4531 |
| Popis: | Prostate cancer is the second most commonly diagnosed neoplasm in men. This neoplasm has usually excellent prognosis, mostly consequent to the early diagnosis and the effective hormonal therapy. However, significant percentages of patients treated with total androgen blockade therapy, escape to treatment and evolve toward a more aggressive type of cancer. This clinical entity, named castration-resistant prostate cancer, has few and less effective therapeutic opportunities. Therefore, any additional information concerning possible biological targets to therapy is welcome. Here we describe two cases in which 68Ga-DOTANOC PET/CT evidenced the somatostatin receptor overexpression by prostate metastases. The presence of these receptors may support with a more strong evidence the possibility to administer somatostatin analogs as an adjuvant therapy. |
| Databáze: | OpenAIRE |
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