In Vitro Studies of Calcitonin Release in Man
| Autor: | R. H. Snider, Selawry Hp, Kenneth L. Becker, O. L. Silva, L E Bivins |
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| Rok vydání: | 1975 |
| Předmět: |
Calcitonin
medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry Thyroid Gland chemistry.chemical_element In Vitro Techniques Calcium Biochemistry Glucagon Phosphates chemistry.chemical_compound Endocrinology Theophylline Internal medicine Cyclic AMP medicine Humans Magnesium Chemistry Biochemistry (medical) General Medicine Phosphate In vitro Pentagastrin Bucladesine Gastrointestinal hormone hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Hormone and Metabolic Research. 7:432-437 |
| ISSN: | 1439-4286 0018-5043 |
| DOI: | 10.1055/s-0028-1093700 |
| Popis: | The influence of various agents on calcitonin release from human thyroid was studied in vitro. Under the condition of this investigation, calcium, magnesium and phosphate did not stimulate calcitonin release from short-term incubated slices of human thyroid. However, pentagastrin and USP glucagon were potent stimulators of calcitonin release. Theophylline and dibutyryl cyclic AMP were also potent stimuli. A highly purified preparation of pancreatic glucagon was without an effect. Those agents which stimulated calcitonin release were associated with augmented cyclic AMP accumulation. Although maximal discharge of calcitonin required the presence of calcium, out in vitro experiments raise the question as to whether a gastrointestinal hormone, rather than calcium, might not be the principal agent affecting calcitonin release. |
| Databáze: | OpenAIRE |
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