Elevated urinary level of vitamin D-binding protein as a novel biomarker for diabetic nephropathy
| Autor: | Yancheng Xu, Yan Zhang, Jiapu Ge, Li-min Zhao, Xiao-Qin Tian |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Cancer Research
Creatinine medicine.medical_specialty business.industry Vitamin D-binding protein Urinary system diabetic nephropathy General Medicine Urine Articles medicine.disease Gastroenterology urine Diabetic nephropathy Excretion chemistry.chemical_compound Immunology and Microbiology (miscellaneous) chemistry Internal medicine Immunology vitamin D binding protein Medicine Biomarker (medicine) Microalbuminuria business |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-1015 1792-0981 |
| Popis: | Improving the early prediction and detection of diabetic nephropathy (DN) remains a great challenge in disease management. The aim of this study was to evaluate the early detection power of urinary vitamin D-binding protein (VDBP) for the diagnosis of DN. Urine samples were obtained from 45 healthy volunteers and 105 diabetic patients with normoalbuminuria (DM group), microalbuminuria (DN1 group) and macroalbuminuria (DN2 group) (n=35 per group). The VDBP expression patterns in urine from patients and controls were quantified by western blot analysis. The excretion levels of urinary VDBP were quantified with enzyme-linked immunosorbent assay. The quantification results were obtained by correcting for creatinine expression and showed that urinary VDBP levels were significantly elevated in the patients of the DN1 and DN2 groups compared with those of the DM group and normal controls (1,011.33±325.30 and 1,406.34±239.66 compared with 466.54±213.63 and 125.48±98.27 ng/mg, respectively) (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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