Does artesunate prolong the electrocardiograph QT interval in patients with severe malaria?
| Autor: | Nicholas P. J. Day, Josh Hanson, M. Gofranul Hoque, Emran Bin Yunus, Katherine Plewes, Prakaykaew Charunwatthana, Arjen M. Dondorp, Niklas Lindegardh, Sue J. Lee, Richard J. Maude, Joel Tarning, M. Abul Faiz, Amir Hossain, Nicholas J. White, Mahatab Uddin Hasan |
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| Předmět: |
Adult
Male Heart block Artemotil Long QT syndrome Artesunate Blood Pressure QT interval Antimalarials Electrocardiography chemistry.chemical_compound Bolus (medicine) Heart Rate Virology parasitic diseases medicine Humans Glasgow Coma Scale cardiovascular diseases Artemether PR interval Fluorenes Lumefantrine business.industry Patient Selection Articles medicine.disease Artemisinins Malaria Long QT Syndrome Infectious Diseases chemistry Ethanolamines Anesthesia cardiovascular system Parasitology business medicine.drug |
| Zdroj: | Scopus-Elsevier The American Journal of Tropical Medicine and Hygiene |
| Popis: | Several antimalarials can cause significant prolongation of the electrocardiograph QT interval, which can be associated with an increased risk of potentially lethal ventricular arrhythmias. High doses of artemether and artemotil have been associated with QT prolongation in dogs, raising the possibility of a class effect with the artemisinin derivatives. Serial electrocardiograms were recorded, and QTc interval was calculated before and after administration of artesunate by intravenous injection in patients with severe falciparum malaria in Bangladesh. Of 21 adult patients with severe malaria enrolled, 8 (38%) died. The mean QTc interval was unaffected by bolus intravenous artesunate (2.4 mg/kg). In two patients, the QTc interval exceeded 0.5 seconds, but in both cases, an alternative explanation was plausible. No effect was observed on the JTc or PR interval, QRS width, blood pressure, or heart rate. Intravenous artesunate does not have significant cardiovascular effects in patients with severe falciparum malaria. |
| Databáze: | OpenAIRE |
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