Device-Based Modulation of Neurocircuits as a Therapeutic for Psychiatric Disorders
| Autor: | Sarah H. Lisanby, Shriya Awasthi, Nicholas L. Balderston, Bruce Luber, William C. Altekruse, Shannon L. Exley, Zhi-De Deng, Michelle M. Noh, Jeena Thomas, Melbaliz Velez Afanador |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pharmacology medicine.medical_specialty Convulsive Therapy business.industry Mental Disorders Brain Electric Stimulation Therapy Equipment Design Toxicology Neurosurgical Procedures Article Neuromodulation (medicine) 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Animals Humans Medicine business Psychiatry 030217 neurology & neurosurgery |
| Zdroj: | Annu Rev Pharmacol Toxicol |
| ISSN: | 1545-4304 0362-1642 |
| DOI: | 10.1146/annurev-pharmtox-010919-023253 |
| Popis: | Device-based neuromodulation of brain circuits is emerging as a promising new approach in the study and treatment of psychiatric disorders. This work presents recent advances in the development of tools for identifying neurocircuits as therapeutic targets and in tools for modulating neurocircuits. We review clinical evidence for the therapeutic efficacy of circuit modulation with a range of brain stimulation approaches, including subthreshold, subconvulsive, convulsive, and neurosurgical techniques. We further discuss strategies for enhancing the precision and efficacy of neuromodulatory techniques. Finally, we survey cutting-edge research in therapeutic circuit modulation using novel paradigms and next-generation devices. |
| Databáze: | OpenAIRE |
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