Does renal function affect gadolinium deposition in the brain?
| Autor: | Cagri Kesim, Seda Kibaroğlu, Hale Turnaoğlu, Kemal Murat Haberal, Ahmet Muhtesem Agildere, Feride Kural Rahatli, Fuldem Yildirim Donmez |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Gadolinium DTPA Male Cerebellum medicine.medical_specialty medicine.medical_treatment Thalamus Urology Contrast Media Renal function Neuroimaging Globus Pallidus 030218 nuclear medicine & medical imaging Young Adult 03 medical and health sciences 0302 clinical medicine Renal Dialysis Humans Medicine Radiology Nuclear Medicine and imaging Renal Insufficiency Aged Retrospective Studies medicine.diagnostic_test business.industry Dose-Response Relationship Radiation Magnetic resonance imaging General Medicine Middle Aged Magnetic Resonance Imaging Pons Dentate nucleus medicine.anatomical_structure Globus pallidus Cerebellar Nuclei nervous system Female Hemodialysis business 030217 neurology & neurosurgery |
| Zdroj: | European Journal of Radiology. 104:33-37 |
| ISSN: | 0720-048X |
| DOI: | 10.1016/j.ejrad.2018.04.017 |
| Popis: | Objective Was to compare T1 signal intensity ratios of dentate nucleus to cerebellar white matter (DN/cerebellum), dentate nucleus to pons (DN/pons) and globus pallidus to thalamus (GP/thalamus) in patients with normal renal function and in patients on chronic hemodialysis. To find out if renal function affects the deposition of gadolinium in brain after administration of linear gadolinium based contrast agents (GBCA). Methods Seventy eight contrast enhanced brain MRIs (Magnetic Resonance Imaging) with linear GBCA of 13 patients on chronic hemodialysis and 13 patients with normal renal function retrospectively evaluated. The DN/pons, DN/cerebellum and GP/thalamus signal intensity ratios were measured from each brain MRI on unenhanced axial T1 weighted images. Results In hemodialysis group statistically significant increase in the signal intensity ratios of DN/pons, DN/cerebellum and GP/thalamus were found between the first and the last brain MRIs (p = .001). The increase in the signal intensity ratios of DN/pons, DN/cerebellum and GP/thalamus between the first and the last brain MRIs in control group were not significant (p > 0.05). The signal intensity increase in DN and globus pallidus were significantly higher in hemodialysis group than control group (p Conclusions Patients on hemodialysis had significantly higher DN and GP signal intensity increase compared to the patients with normal renal function. Renal function affects the rate of gadolinium deposition in the brain after administration of linear GBCA. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect