HLA Status in Patients with Chronic Spontaneous Urticaria
| Autor: | Alicja Grzanka, Jolanta Polanska, Jerzy Jarzab, Andrzej Bozek, Jolanta Krajewska, Barbara Filipowska, Regina Rachowska |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Adolescent Urticaria Immunology Human leukocyte antigen Immunoglobulin E law.invention HLA-B44 Antigen Gene Frequency Antigen law Immunopathology Humans Immunology and Allergy Medicine Genetic Predisposition to Disease Allele Allele frequency Genetic Association Studies Polymerase chain reaction Chronic urticaria Aged Polymorphism Genetic HLA-A Antigens biology business.industry Histocompatibility Testing HLA-DR Antigens General Medicine Middle Aged HLA-B Antigens Chronic Disease biology.protein Female Poland business HLA-DRB1 Chains |
| Zdroj: | International Archives of Allergy and Immunology. 153:419-423 |
| ISSN: | 1423-0097 1018-2438 |
| DOI: | 10.1159/000316354 |
| Popis: | Chronic spontaneous urticaria (CSU) is the most common form of chronic urticaria. A considerable amount of data supports an immunological basis for CSU. Some research has focused on the association between chronic urticaria and specific human leukocyte antigen (HLA) alleles. The aim of this study was to investigate the HLA status of Polish patients diagnosed with CSU. Methods: The standard complement-dependent microlymphocytotoxicity assay and PCR amplification with sequence-specific primers were used to analyze HLA alleles in 115 patients diagnosed with CSU, and the results were compared to those from 162 healthy, genetically unrelated individuals. Results: Among the HLA-A alleles, A-33 occurred significantly more often in the control group (p < 0.01). Analysis of the HLA-B allele frequencies revealed the prevalence of the B44 antigen in the study group (p < 0.0001). Frequencies of HLA-C alleles and HLA-DQ did not differ significantly between the groups. Among the HLA class II alleles, DRB1*04 was observed significantly more often in the study population (p < 0.001), mainly in the autoimmunological subtype of urticaria. Conclusion: HLA alleles may be involved in CSU development or play a protective role in CSU. |
| Databáze: | OpenAIRE |
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