Suppression of plasma hepcidin by venesection during steady-state hypoxia

Autor:	David R. Mole, Cafer Gülsever, Samira Lakhal-Littleton, Thomas G. Smith, Peter A. Robbins, Keith L. Dorrington, Maria Rivera-Ch, Nick P. Talbot
Rok vydání:	2016
Předmět:	Adult Male inorganic chemicals 0301 basic medicine congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Immunology Altitude Sickness Biology digestive system Biochemistry Hypoxia/blood Hepcidins/blood 03 medical and health sciences Hepcidins Phlebotomy Hepcidin hemic and lymphatic diseases Internal medicine medicine Increased iron Humans Hypoxia Altitude sickness Iron uptake Altitude nutritional and metabolic diseases Cell Biology Hematology Mononuclear phagocyte system Hypoxia (medical) medicine.disease purl.org/pe-repo/ocde/ford#3.01.03 [https] purl.org/pe-repo/ocde/ford#3.02.06 [https] 030104 developmental biology Endocrinology biology.protein Erythropoiesis medicine.symptom
Zdroj:	Blood. 127:1206-1207
ISSN:	1528-0020 0006-4971
DOI:	10.1182/blood-2015-05-647404
Popis:	Hepcidin inhibits iron uptake from the gut and release of iron from macrophages in the reticuloendothelial system. Suppression of plasma hepcidin occurs in lowlanders after ascent to high altitude, reflecting the increased iron demand for erythropoiesis, but the mechanism and primary stimulus for hepcidin suppression in this setting remains unclear...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c48c97240948a76468715e0d27e4c2 https://doi.org/10.1182/blood-2015-05-647404 Zobrazit plný text záznamu