The Role of Tumor-Derived Vesicles in the Regulation of Antitumor Immunity
| Autor: | V. M. Ukrainskaya, Michael Maschan, Alexey Stepanov, Yury P. Rubtsov, V. D. Knorre, A. G. Gabibov |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Tumor microenvironment vesicles Chemistry Vesicle exosomes Tumor-Derived Biochemistry Microvesicles immune response Cell biology 03 medical and health sciences Crosstalk (biology) 030104 developmental biology 0302 clinical medicine Immune system 030220 oncology & carcinogenesis Molecular Medicine CD4+/CD8+ T cells tumor microenvironment Molecular Biology Intracellular Biogenesis Biotechnology Research Article |
| Zdroj: | Acta Naturae |
| ISSN: | 2075-8251 |
| Popis: | In this article, we present a comprehensive, updated, and elucidative review of the current knowledge on the function played by tumor-derived vesicles (TDVs) in the crosstalk between tumor and immune cells. Characterization of the structure, biogenesis, and the major functions of TDVs is reported. The review focuses on particular ways of suppression or activation of CD4+/CD8+ Т cells by tumor-derived vesicles. Tumor-derived vesicles play an important role in the suppression of antitumor immunity. During the last 15 years, vesicle research has elucidated and improved our knowledge about the role of the vesicles in intercellular communication. Nevertheless, there are still blinds spots concerning vesicle heterogeneity and isolation methods, their uptake by target cells, and the role of mRNA in T-cell transformation or suppression. Along with the substantial progress in understanding of the role of tumor-derived vesicles in intercellular communication, novel antitumor therapy strategies based on vesicle inhibition in a tumor microenvironment are likely to appear very soon. |
| Databáze: | OpenAIRE |
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