Effect of intraoperative infusion of dexmedetomidine on postoperative recovery in patients undergoing endovascular interventional therapies: A prospective, randomized, controlled trial

Autor: Zongwang Zhang, Guoying Liu, Huiying Xu, Guangjun Xu, Jun-Li Cao, Chunguang Ren, Lei Liu
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Sedation
endovascular interventional therapies
Urapidil
050105 experimental psychology
Pacu
lcsh:RC321-571
Sufentanil
03 medical and health sciences
Behavioral Neuroscience
Postoperative Complications
0302 clinical medicine
Cerebral vasospasm
Double-Blind Method
medicine
Humans
0501 psychology and cognitive sciences
Postoperative Period
Prospective Studies
Dexmedetomidine
Infusions
Intravenous
Nimodipine
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Aged
Original Research
Intraoperative Care
biology
business.industry
Endovascular Procedures
05 social sciences
Hemodynamics
Glasgow Coma Scale
dexmedetomidine
Analgesics
Non-Narcotic
Middle Aged
nimodipine
biology.organism_classification
Anesthesia
cerebral vasospasm
Female
medicine.symptom
business
030217 neurology & neurosurgery
neuroanesthesia
medicine.drug
Zdroj: Brain and Behavior, Vol 9, Iss 7, Pp n/a-n/a (2019)
Brain and Behavior
ISSN: 2162-3279
Popis: Background Rapid emergence from general anesthesia during endovascular interventional therapies (EITs) is important. However, the solution that improved quality of both analepsia and postoperative recovery after EITs has not been specifically addressed. We conducted this prospective, randomized, controlled trial to evaluate the intraoperative infusion of dexmedetomidine on quality of analepsia and postoperative recovery in patients undergoing EITs. Methods Eighty‐six patients undergoing EITs were divided into three groups: RD1 (dexmedetomidine at an initial dose of 0.5 μg/kg for 10 min adjusted to 0.2 μg kg−1 hr−1 throughout EIT), RD2 (dexmedetomidine at an initial dose of 0.5 μg/kg for 10 min adjusted to 0.4 μg kg−1 hr−1 throughout EIT), and RD3 (dexmedetomidine at an initial dose of 0.5 μg/kg for 10 min adjusted to 0.6 μg kg−1 hr−1 throughout EIT). An analgesia system delivered sufentanil only. The primary outcome measure was the total consumption of nimodipine during the first 48 hr after surgery. The secondary outcome measures were sufentanil consumption, pain intensity, hemodynamics, functional activity score (FAS), neurologic examination, level of sedation (LOS), and Bruggrmann comfort scale (BCS). We also recorded the intraoperative hemodynamic data, requirement of narcotic and vasoactive drugs, prevalence of complications and symptomatic cerebral vasospasm, duration of postanesthesia care unit (PACU) stay, Glasgow Outcome Score (GOS) at 3 months, and prevalence of cerebral infarction 30 days after surgery. Results Dexmedetomidine application in the regimen RD3 reduced the consumption of the total dose of nimodipine and sufentanil 48 hr after surgery, prevalence of symptomatic cerebral vasospasm, consumption of narcotic drugs and nimodipine during surgery, pain intensity during the first 8 hr after surgery, and increased both BCS during the first 4 hr after surgery and hemodynamic stability. However, the LOS was increased at the 0.5 hr after surgery and surgeon satisfaction score was lower. There were no significant differences among the groups for consumption of vasoactive drugs except urapidil, Glasgow coma scale (GCS) and FAS during the first 48 hr after surgery, GOS at 3 months, and cerebral infarction after 30 days. Conclusions Dexmedetomidine (an initial dose of 0.5 μg/kg for 10 min adjusted to 0.6 μg kg−1 hr−1 throughout EIT) could reduce the total consumption of nimodipine and opioid during the first 48 hr after surgery, the concerning adverse effects, and improve pain scores. The optimal dosage of dexmedetomidine during EITs merits further investigation.
Databáze: OpenAIRE
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