Nanoparticle formation of PVP/astaxanthin inclusion complex by solution-enhanced dispersion by supercritical fluids (SEDS): Effect of PVP and astaxanthin Z -isomer content
| Autor: | Kahori Kaga, Masatoshi Honjo, Motonobu Goto, Masaki Honda, Hideki Kanda, Wahyudiono, Adachi Tomoki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
General Chemical Engineering
Nanoparticle 02 engineering and technology 01 natural sciences E/Z isomerization chemistry.chemical_compound Astaxanthin Coprecipitation medicine Physical and Theoretical Chemistry Carotenoid Polyvinylpyrrolidone 010405 organic chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics Supercritical fluid 0104 chemical sciences Bioavailability Antioxidant capacity chemistry Supercritical anti-solvent Particle size 0210 nano-technology Dispersion (chemistry) medicine.drug Nuclear chemistry |
| Zdroj: | The Journal of Supercritical Fluids. 136:44-51 |
| ISSN: | 0896-8446 |
| Popis: | The effects of operating conditions and Z-isomer content of astaxanthin on coprecipitate formation of polyvinylpyrrolidone (PVP) and astaxanthin by solution-enhanced dispersion by supercritical fluids (SEDS) process were investigated. Using this process, nano-sized (100–200 nm) and water-soluble PVP/astaxanthin inclusion complex was successfully prepared. As the operating pressure increased from 8 to 15 MPa at a constant temperature, astaxanthin content in the coprecipitates decreased, and increasing the operating temperature from 40 to 60 °C at a constant pressure, the particle size and the astaxanthin content increased. Increasing the PVP ratio for astaxanthin in the range of 5:1 to 20:1, the particle size decreased and when 10:1 of the ratio, the astaxanthin content in the coprecipitates was the highest (60 °C, 10 MPa). Additionally, as the Z-isomer content of astaxanthin increased, the astaxanthin content decreased slightly. However, the coprecipitates rich in astaxanthin Z-isomers, which have higher bioavailability and antioxidant capacity, were obtained. ファイル公開：2020-06-01 |
| Databáze: | OpenAIRE |
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