Evaluation of Insulin Like Growth Facror-1 Genetic Polymorphism with Gastric Cancer Susceptibility and Clinicopathological Features
Autor: | Hamid Asadzadeh Aghdae, Elham Rostami, Habib Malekpour, Mohamad Amin Pourhoseingholi, Pedram Azimzadeh, Roya Kishani Farahani, Mohammad Reza Zali, Ehsan Nazemalhosseini Mojarad |
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Rok vydání: | 2015 |
Předmět: |
Adult
Cancer Research medicine.medical_specialty Pathology Genotype Epidemiology medicine.medical_treatment Single-nucleotide polymorphism Iran Biology Logistic regression Polymorphism Single Nucleotide Gastroenterology Metastasis Young Adult Risk Factors Stomach Neoplasms Internal medicine Biomarkers Tumor medicine Humans Genetic Predisposition to Disease Insulin-Like Growth Factor I Allele Aged Neoplasm Staging Aged 80 and over Insulin Public Health Environmental and Occupational Health Middle Aged medicine.disease Oncology Apoptosis Case-Control Studies Gene polymorphism Neoplasm Grading |
Zdroj: | Asian Pacific Journal of Cancer Prevention. 16:4215-4218 |
ISSN: | 1513-7368 |
Popis: | Gastric cancer (GC) is one of the most common malignancies in the world. It is the first cause of cancer deaths in both sexes In Iranian population. Circulating insulin-like growth factor-one (IGF-1) levels have been associated for gastric cancer. IGF-1 protein has central roles involved in the regulation of epithelial cell growth, proliferation, transformation, apoptosis and metastasis. Single nucleotide polymorphism in IGF-1 regulatory elements may lead to alter in IGF-1 expression level and GC susceptibility. The aim of this study was to investigate the influence of IGF-1 gene polymorphism (rs5742612) on risk of GC and clinicopathological features for the first time in Iranian population. In total, 241 subjects including 100 patients with GC and 141 healthy controls were recruited in our study. Genotypes were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay with DNA from peripheral blood. The polymorphism was statistically analyzed to investigate the relationship with the risk of GC and clinicopathological properties. Logistic regression analysis revealed that there was no significant association between rs5742612 and the risk of GC. In addition, no significant association between genotypes and clinicopathological features was observed (p value>0.05). The frequencies of the CC, CT, and TT genotypes were 97%, 3%, and 0%, respectively, among the cases, and 97.9%, 2.1%, and 0%, respectively, among the controls. CC genotype was more frequent in cases and controls. The frequencies of C and T alleles were 98.9% and 1.1% in controls and 98.5% and 1.5% in patient respectively. Our results provide the first evidence that this variant is rare in Iranian population and it may not be a powerful genetic predisposing biomarker for prediction GC clinicopathological features in an Iranian population. |
Databáze: | OpenAIRE |
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