Large dose hyperpolarized water with dissolution-DNP at high magnetic field
| Autor: | Jan Henrik Ardenkjær-Larsen, Kasper Wigh Lipsø, Oleksandr Rybalko, Sean Bowen |
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| Rok vydání: | 2017 |
| Předmět: |
Nuclear and High Energy Physics
Proton Biophysics Analytical chemistry 010402 general chemistry 01 natural sciences Biochemistry 030218 nuclear medicine & medical imaging law.invention 03 medical and health sciences 0302 clinical medicine Nuclear magnetic resonance law Large dose Hyperpolarization (physics) Dissolution Thermal equilibrium Hyperpolarized water Chemistry Polarizer Condensed Matter Physics Polarization (waves) 0104 chemical sciences Hyperpolarization Dissolution-DNP High magnetic field |
| Zdroj: | Lipsø, H K W, Bowen, S, Rybalko, O & Ardenkjær-Larsen, J H 2016, ' Large dose hyperpolarized water with dissolution-DNP at high magnetic field ', Journal of Magnetic Resonance, vol. 274, pp. 65-72 . https://doi.org/10.1016/j.jmr.2016.11.008 |
| ISSN: | 1090-7807 |
| DOI: | 10.1016/j.jmr.2016.11.008 |
| Popis: | We demonstrate a method for the preparation of hyperpolarized water by dissolution Dynamic Nuclear Polarization at high magnetic field. Protons were polarized at 6.7T and 1.1K to >70% with frequency modulated microwave irradiation at 188GHz. 97.2±0.7% of the radical was extracted from the sample in the dissolution in a two-phase system. 16±1mL of 5.0M (1)H in D2O with a polarization of 13.0±0.9% in the liquid state was obtained, corresponding to an enhancement factor of 4000±300 compared to the thermal equilibrium at 9.4T and 293K. A longitudinal relaxation time constant of 16±1s was measured. The sample was polarized and dissolved in a fluid path compatible with clinical polarizers. The volume of hyperpolarized water produced by this method enables angiography and perfusion measurements in large animals, as well as NMR experiments for studies of e.g. proton exchange and polarization transfer to other nuclei. |
| Databáze: | OpenAIRE |
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