Dietary patterns, food groups and nutrients in Crohn’s disease: associations with gut and systemic inflammation
| Autor: | Subrata Ghosh, Raylene A. Reimer, Lorian M. Taylor, S. Ali Naqvi, Naomi Hotte, Sandeep Kaur, Maitreyi Raman, Karen Madsen, Nusrat S. Shommu, Remo Panaccione, Herman W. Barkema |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Mediterranean diet Science medicine.medical_treatment Diseases Disease Diet Mediterranean Systemic inflammation Severity of Illness Index Gastroenterology Article Food group Eating Feces 03 medical and health sciences Medical research 0302 clinical medicine Crohn Disease Internal medicine medicine Humans Inflammation Crohn's disease Multidisciplinary business.industry Nutrients Middle Aged medicine.disease C-Reactive Protein 030104 developmental biology Cytokine Cytokines Medicine Female 030211 gastroenterology & hepatology Calprotectin medicine.symptom business Leukocyte L1 Antigen Complex Biomarkers |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | This study examined associations between dietary intake and gut and systemic inflammation assessed by fecal calprotectin ≤ or > 100 μg/mg (FCP), C-reactive protein ≤ or > 5 mg/L (CRP) and serum cytokine profiles in Crohn’s disease (CD) patients in clinical remission. A 3-month observational study was conducted at the University of Calgary in Calgary, Alberta, Canada between 2016 and 2018 in 66 outpatients with CD in clinical remission. FCP was obtained from stool samples at baseline and 3-months and serum CRP and serum cytokines were assessed at 3-months only (n = 41). Dietary intakes were collected using 3-day food records at baseline and 3-months and categorized as: PREDIMED Mediterranean diet scores (pMDS) total and individual components, the dietary inflammatory index (DII), food groups, and common micro- and macro-nutrients. Statistical models were developed to identify relationships between dietary factors and FCP, CRP and cytokine levels. Daily intake of leafy green vegetables was associated with FCP ≤ 100 μg/mg (p p = 0.02). Different cytokines were significantly associated with various dietary variables. Future studies in patients with greater disease activity should be undertaken to explore these relationships. |
| Databáze: | OpenAIRE |
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