The effects of addition of functional monomers and molecular imprinting on dual drug release from intraocular lens material
| Autor: | Ana Topete, Benilde Saramago, Jorge A. Saraiva, Luís F. Santos, Isabel Barahona, Ana Paula Serro, Carlos A. Pinto |
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| Rok vydání: | 2021 |
| Předmět: |
Staphylococcus aureus
Diclofenac medicine.drug_class medicine.medical_treatment Moxifloxacin Antibiotics Pharmaceutical Science Intraocular lens 02 engineering and technology Functional monomers Pharmacology 030226 pharmacology & pharmacy Molecular Imprinting 03 medical and health sciences 0302 clinical medicine Endophthalmitis medicine Lenses Intraocular Chemistry Hydrogels Cataract surgery 021001 nanoscience & nanotechnology medicine.disease Anti-Bacterial Agents Bioavailability Drug Liberation Drug delivery 0210 nano-technology Molecular imprinting medicine.drug |
| Zdroj: | International Journal of Pharmaceutics. 600:120513 |
| ISSN: | 0378-5173 |
| Popis: | Although cataract surgery is considered a safe procedure, post-surgery complications such as endophthalmitis and ocular inflammation, may occur. To prevent this, antibiotics and anti-inflammatories are prescribed in the form of eye drops during the post-operatory period, but they lead to a low drug bioavailability in target tissues. The objective of this work is to develop an intraocular lens (IOL) material to deliver simultaneously one antibiotic, moxifloxacin (MXF), and one anti-inflammatory, diclofenac (DFN), in therapeutic concentrations to prevent both complications. The IOL material was modified through the incorporation of functional monomers, as well as molecular imprinting with both drugs using the same functional monomers, namely acrylic acid (AA), methacrylic acid (MAA), 4-vinylpiridine (4-VP) and a combination of MAA + 4-VP. The best results were obtained with MAA. Molecular imprinting did not influence the drug release, except with AA. Application of a mathematical model predicted that the released MXF and DFN concentrations would stay above the pre-determined MIC of S. aureus and S. epidermidis and the minimum values of IC50 of COX-1 and COX-2, for 9 and 14 days, respectively. Antibacterial tests showed that the released antibiotic remained active. The physical properties of the drug-loaded MAA-hydrogel remained adequate. The developed system proved to be non-irritant and non-cytotoxic. |
| Databáze: | OpenAIRE |
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