Down for the count: The critical endpoint in ototoxicity remains the cytocochleogram
| Autor: | David V. Gauvin, Rachel Tapp, Joshua Yoder, Andrea A. Koch, Zachary J. Zimmermann |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pharmacology
medicine.medical_specialty Endpoint Determination business.industry Audiology Toxicology medicine.disease Anti-Bacterial Agents Cochlea 03 medical and health sciences 0302 clinical medicine Acoustic Stimulation Species Specificity Ototoxicity Evoked Potentials Auditory Brain Stem otorhinolaryngologic diseases Animals Humans Medicine sense organs Gentamicins 030223 otorhinolaryngology business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Pharmacological and Toxicological Methods. 88:123-129 |
| ISSN: | 1056-8719 |
| Popis: | There are three major assays that must be conducted in standard investigational new drug (IND) -enabling ototoxicity study designs: 1) functional acoustic threshold measurements (Auditory Brainstem Respsonse, ABR); 2) otohistopathology and 3) cytocochleograms. We provide evidence to demonstrate the unreliability of auditory threshold shifts (ABRs) to predict cochlear cell death and build a case for conducting full cochlea processing and cell count measurements from the complete cochlea from apex to base. |
| Databáze: | OpenAIRE |
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